By Pooya Khan Mohammad Beigi, Emanual Maverakis
This new textual content presents perception and healing procedures for the coated sickness, together with dozens of top of the range photos, illustrations, and scientific tables. subject matters lined contain the heritage of the affliction, different types of the disease, molecular research, epidemiology, results on physique structures, sickness signs, and therapy. Acrodermatitis Enteropathica is a unprecedented sickness of zinc metabolism that happens in a single of 2 kinds: inborn and purchased. If untreated, the illness is deadly and affected participants could die inside quite a few years, yet when you consider that there is not any treatment for the situation, it's serious that physicians are conscious of the symptoms regarding AE and the best remedies to be had for sufferers. A accomplished advisor to Acrodermatitis Enteropathica is the single ebook of its style to offer perception into this infrequent disease. Written by means of and for dermatologists, pediatric experts, and ObGYN’s, this publication includes one of many greatest medical learn stories performed on Acrodermatitis Enteropathica during the last decade.
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Extra resources for Acrodermatitis Enteropathica: A Clinician's Guide
The ligand present in bovine milk does not improve zinc absorption; as a result AE symptoms often appear when the infants’ diet is switched to bovine milk . Casey, Walravens, et al. 2 Etiology 11 function . Recently, researchers have hypothesized that AE may be caused by a mutation in the gene SLC39A4 coding for the hZip4 Zn transporter present in intestinal cells of the intestine [3, 4]. This hypothesis is supported by studies that have concluded that AE patients and healthy individuals have similar duodenal ZBL secretions or that the amount of ZBL present in the intestine is insignificant in zinc absorption [16, 21].
Brandt T. Dermatitis in children with disturbances of the general condition and the absorption of food elements. Acta Derm. 1936;17:513–46. 3. Danbolt N, Closs K. Akrodermatitis enteropathica. Acta Derm Venerol. 1942;23:127–69. 4. Michalczyk AA, Ackland ML. hZip1 (hSLC39A1) regulates zinc homoeostasis in gut epithelial cells. Genes Nutr. 2013;8(5):475–86. 5. Van Wouwe JP. Clinical and laboratory assessment of zinc deficiency in Dutch children. A review. Biol Trace Elem Res. 1995;49(2-3):211–25.
Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem. 2004;279(6):4523–30. 52. Andrews GK. Regulation and function of Zip4, the acrodermatitis enteropathica gene. Biochem Soc Trans. 2008;36(Pt 6): 1242–6. 53. Dufner-Beattie J, et al. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. J Biol Chem. 2003;278(35):33474–81. 54. Dufner-Beattie J, et al. The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.
Acrodermatitis Enteropathica: A Clinician's Guide by Pooya Khan Mohammad Beigi, Emanual Maverakis