By Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain
Written for researchers, teachers and pros, those papers signify an integral reference resource at the newest developments and findings within the box of proteins, amino acids and peptides. content material: Preface; Amino acid and petide bioconjugates; Self-assembling peptide fabrics; steel complexes of amino acids and peptides; version structures for folding and teriary contacts in peptides: A viewpoint from the actual sciences; Protein nanotubes, channels and cages; Prescriptive peptide layout; concentrating on alpha-helix established protein interactions - nuclear receptors as a case research summary: Written for researchers, teachers and pros, those papers characterize an crucial reference resource at the most recent tendencies and findings within the box of proteins, amino acids and peptides
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Extra info for Amino Acids, Peptides and Proteins Vol. 37
R1 N3 + R 2 Cu(I) R1 R2 N N N R2 R1 N3 + R2 Ru(II) R1 N N N Scheme 12 The metal catalyzed 1,3-dipolar azide-alkyne cycloaddition. 67 A click chemistry reaction by deﬁnition should be modular, stereospeciﬁc and give very high yields. Moreover these reactions are based on readily available starting materials, simple reaction conditions (ideally, the process should be insensitive to oxygen and water) and generate inoﬀensive by-products. Copper(I) and ruthenium(I) are the most commonly used catalysts in the reaction.
B. Blanco-Canosa, I. L. Medintz, D. Farrell, H. Mattoussi and P. E. Dawson, J Am Chem Soc, 2010, 132, 10027. G. Iyer, F. Pinaud, J. Xu, Y. Ebenstein, J. Li, J. Chang, M. Dahan and S. Weiss, Bioconjug Chem, 2011, 22, 1006. F. M. Brunel, J. D. Lewis, G. Destito, N. F. Steinmetz, M. Manchester, H. Stuhlmann and P. E. Dawson, Nano Letters, 2010, 10, 1093. D. E. Prasuhn, J. B. Blanco-Canosa, G. J. Vora, J. B. Delehanty, K. Susumu, B. C. Mei, P. E. Dawson and I. L. Medintz, ACS Nano, 2010, 4, 267. A.
Proteins, 2012, 37, 1–39 Recently, very comprehensive reviews on peptide-based probes for molecular imaging were published by research group of X. 201,202 The current state of development of peptide heterodimers as dual-targeted molecular probes is discussed by Y. 203 and their utilization for in vivo cancer imaging was discussed by Z. Liu and F. 204 L. 200 This c(RGDyK)-conjugated MMP ﬂuorogenic probe eﬃciently targeted both aVb3 integrin- and MMP-overexpressing U87MG tumour-bearing mouse model.
Amino Acids, Peptides and Proteins Vol. 37 by Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain