By Lawrence E. Hunter
The huge, immense quantity of knowledge generated by means of the Human Genome undertaking and different large-scale organic learn has created a wealthy and demanding area for study in synthetic intelligence. those unique contributions offer a present sampling of AI techniques to difficulties of organic importance; they're the 1st to regard the computational wishes of the biology neighborhood hand-in-hand with applicable advances in synthetic intelligence. targeting novel applied sciences and techniques, instead of on confirmed functions, they conceal genetic series research, protein constitution illustration and prediction, computerized facts research aids, and simulation of organic structures. a quick introductory primer on molecular biology and Al supplies machine scientists enough heritage to appreciate a lot of the biology mentioned within the book.Lawrence Hunter is Director of the desktop studying venture on the nationwide Library of drugs, nationwide Institutes of Health.
Though this can be a previous booklet (from 1993) nonetheless has solid primers &touches introductory topics.
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Additional info for Artificial Intelligence and Molecular Biology (American Association for Artificial Intelligence)
First, short sequences of DNA (called oligonucleotides, or oligos) complementary to *There are many interesting uses of this technology. For example, it gives law enforcement the ability to generate enough DNA for identification from vanishing small samples of tissue. A more amusing application is the rumored use of PCR to spy on what academic competitors are doing in their research. Almost any correspondence from a competitor’s lab will contain traces of DNA which can be amplified by PCR to identify the specific clones the lab is working with.
Cloning. A group of cells with identical genomes are said to be clones of one another. Unless there are mutations, a single cell that reproduces asexually will produce identical offspring; these clones are sometimes called a cell line, and certain standardized cell lines, for example the HeLa cell line, play an important role in biological research. This concept has been generalize to cloning individual genes. In this case, a piece of DNA containing a gene of interest is inserted into the genome of a target cell line, and the cells are screened so that all of the resulting cells have an identical copy of the desired genetic sequence.
The complement to a single-stranded DNA sequence will bind quite specifically to that sequence. One technique measures how similar two related DNA sequences are by testing how strongly the single-stranded versions of the molecules stick to each other, or hybridize. The more easily they come apart, the more differences there are between their sequences. It is also possible to attach a dye or other marker to a specific piece of DNA (called a probe) and then hybridize it to a longer strand of DNA.
Artificial Intelligence and Molecular Biology (American Association for Artificial Intelligence) by Lawrence E. Hunter