Download PDF by Jonathan A. Cotliar: Atlas of Graft-versus-Host Disease: Approaches to Diagnosis

By Jonathan A. Cotliar

ISBN-10: 3319469509

ISBN-13: 9783319469508

ISBN-10: 3319469525

ISBN-13: 9783319469522

This atlas presents trainees and working towards physicians a visible toolkit to aid realize and deal with this hard accurately. this article highlights the medical variability of GVHD, and hands readers with the diagnostic clues to categorize sufferers in keeping with the present grading/staging guidance. moreover, this atlas bargains evidence-based diagnostic and remedy algorithms for physicians to exploit whereas at sufferers' bedsides.

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Extra info for Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment

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Graft-versus-host disease. N Engl J Med. 1991;324(10):667–74.  Differential cytokine expression in acute and chronic murine graft-versus-host-disease. Eur J Immunol. 1993;23(2):333–7. 22.  Dendritic cell subsets and the regulation of Th1/Th2 responses. Semin Immunol. 2001;13(5):275–82. Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, et al. Ruxolitinib in corticosteroid-refractory graft-­ versus-­host disease after allogeneic stem cell transplantation: a multicenter survey.

Significant keratinocyte dysmatu- be the most difficult to distinguish from aGVHD, with each ration and/or cytologic atypia leans toward the diagnosis revealing a sparse lymphocytic interface dermatitis, though of TEC [22]. In addition, TEC also may show dermal SLE is not a common clinical consideration in the period edema, eccrine squamous syringometaplasia, and peri- immediately after transplantation. Findings of increased eccrine neutrophils [26]. Theoretically, TEC is a direct mucin in the superficial dermis may help to distinguish the toxicity effect, a nonimmunologic process that should be two [32].

17 Erythema with deeper desquamation 3 Clinical Presentation of Acute Cutaneous Graft-Versus-Host Disease 27 Bullae Papules Rarely, bullous aGVHD may develop (Fig. 20). Papular aGVHD may mimic papular eczema or papular urticaria (Figs. 22). Fig. 20 Erythema of the right dorsal hand and fingers with a tense bulla on the fourth finger Fig. 21 Erythematous, scaly papules on the right arm and shoulder Fig. A.  Recognition of this variability can ensure that accurate and immediate treatment of aGVHD is initiated to improve outcomes for affected patients.

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Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment by Jonathan A. Cotliar


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