By Sunil R. Lakhani, Caroline J. Finlayson, Susan A. Dilly, Mitesh Gandhi
This re-creation is an easy creation to pathology and the mechanisms of disorder. It places pathology into its old, clinical and scientific context for all scientific, dental and nursing scholars and different future health professionals.
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Extra info for Basic pathology : an introduction to the mechanisms of disease
The latter two act by changing the rate of cell proliferation, and are successful in many types of cancer. The first reported cure with radiotherapy was in 1899 on a basal cell carcinoma of the skin. These are the same as those involved in bacterial killing in inflammation (page 101). All of these produce necrosis and generate a tissue response to the damage, and of course normal as well as tumour cells are affected. In addition, radiation damages DNA (as we shall discuss in chapter 2), producing breaks in the strands.
First the particle must uncoat and separate its genome from its structural components. It then uses specific enzymes of its own or present in the host cell to synthesize viral genome, enzyme and capsid proteins. These must be assembled and released, either directly (unencapsulated viruses) or by budding through the host cell’s membrane (encapsulated viruses). g. g. g. g. g. EBV, papilloma virus, HTLV-1). g. g. muscle cell atrophy after motor neuron damage by polio virus). 11) Nucleic acid RNA Symmetry Icosahedral Envelope No Helical Yes SS1 SS2 Complex Complex SS1 Family Picorna Reo Toga Flavi Corona Orthomyxo Paramyxo Rhabdo Retro Icosahedral No Yes SS linear DS circular DS linear DS linear Parvo Papova Adeno Herpes Complex DS circular DS linear Hepadna Pox Yes DNA Complex Strand SS1 DS SS Example Polio, coxsackie Rotavirus Rubella (rubivirus) Yellow fever Colds Influenza A, B and C Mumps, measles Rabies HIV, HTLV Aplastic anaemia Papillomavirus Colds Herpes simplex Varicella zoster Cytomegalovirus Epstein–Barr virus Hepatitis B Smallpox SS, single strand; DS, double strand.
Which factors are personal to the individual and which are acquired from the environment. The ‘intrinsic’ factors are less simple because our ideas have changed enormously over the last decade as the human genome has been sequenced. It is tempting now to imagine that every ‘intrinsic’ factor could be listed under the category of genetic, just as every idea in this book is composed of letters clustered as words and arranged in sentences. However, a book would not be defined as a collection of letters.
Basic pathology : an introduction to the mechanisms of disease by Sunil R. Lakhani, Caroline J. Finlayson, Susan A. Dilly, Mitesh Gandhi