By T W Goodwin
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Additional info for Biochemistry of Lipids
Thus, although the mechanism for this in vitro effect is not known, and the studies have not yet delineated whether or not there is only an effect of bile salts on amount of HMG-CoA reductase, I return to my first sentence of two paragraphs ago: There is an interdependent control of cholesterol biosynthesis at the level of HMG-CoA reductase. Control may be related to both the amount of enzyme synthesised and the fine-tuning imparted by enzymic effectors. 2 Control at the multi-enzymic level The effects of end-product inhibitors on HMG-CoA reductase was discussed above.
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3 Non-catalytic proteins of the microsomal multi-enzymic system There have been reports of two types of non-catalytic proteins, which may participate in the microsomal system of sterol biosynthesis. These are the structural proteins of membranes and the carrier proteins of sterol biosynthetic intermediates. Soluble enzymes MeCOSCoA
Biochemistry of Lipids by T W Goodwin