By Richard Prayson MD, Bette K. Kleinschmidt-DeMasters MD, Mark Cohen MD, David E. Elder MB ChB
Surgical neuropathology is a difficult area for plenty of pathologists, due largely to a relative loss of event of so much pathologists during this quarter in comparison to different components of surgical pathology. Brain Tumors is meant to deal with this want with situations drawn from the surgical neuropathology practices of the authors.
This quantity offers examples of over a hundred mind tumors, working the gamut from the quite common to the infrequent. every one instance is gifted in a case established structure and the wide range of circumstances awarded covers the complete scope of mind tumors and provides the chance to study either the fundamentals for the newbie or really green pathologist and likewise deals skilled pathologists the opportunity to determine a number of the infrequent entities.
Each case is formatted as though it have been a seek advice case and features a short medical historical past, description of the pathologic findings with a variety of illustrations, the road prognosis, dialogue of the entity, and the diagnostic inspiration strategy besides pertinent references for extra interpreting. while suitable, present sensible functions of immunohistochemistry and molecular pathology are mentioned.
The advisor Pathology Series
The advisor Pathology series is designed to disseminate the information of specialist surgical pathology experts within the research and analysis of adverse circumstances to the complete group of pathology practitioners. The volumes are in accordance with real consultations and awarded in a structure that illustrates the expert's strategy of comparing the case, together with symptoms for session, the experts findings and remark, and dialogue of the entity that amplifies the case description. each one quantity within the Consultant Pathology series is authored via overseas specialists with huge case event within the components covered
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Extra info for Brain Tumors
2. Prayson RA, Abramovich CM. Glioneuronal tumor with neuropil-like islands. Hum Pathol 2000;31:14:35–8. 3. Teo JGC, Gultekin H, Bilsky M, Gutin P, et al. A distinctive glioneuronal tumor of the adult cerebrum with neuropil-like (including “rosetted”) islands. Report of 4 cases. Am J Surg Pathol 1999;23:502–10. Case 7: Glioblastoma Multiforme C L I N I C A L I N F O R M AT I O N The patient is a 72-year-old male who presents with a focally enhancing mass in the right frontal lobe. Biopsies are taken, and histologic sections are reviewed.
High magniﬁcation, showing occasional atypical spindled cells, consistent with inﬁltrating astrocytoma. 3 Another area from the corpus callosum biopsy, showing an increased number of spindled cells. 5 Subpial aggregation of spindled tumor cells is present in the frontal lobe biopsy. 4 The frontal lobe biopsy shows more in the way of cellularity, and a rare mitotic ﬁgure is present. The diagnosis is usually made by correlating the biopsy results with the imaging ﬁndings. Morphologically, the glioma component may resemble an astrocytoma, oligodendroglioma, or mixed glioma.
Lab Invest 1997;76:277–84. 4. Yang HJ, Kim JE, Paek SH, et al. The signiﬁcance of gemistocytes in astrocytoma. Acta Neurochir 2003;145:1097–1103. Case 9: Granular Cell Glioblastoma C L I N I C A L I N F O R M AT I O N necrosis. Vascular proliferative changes are noted at the parameter of the lesion. In areas of vascular proliferation, atypical-appearing astrocytic cells, with high nuclear-to-cytoplasmic ratio and an appearance more typical of a diffuse or ﬁbrillary type astrocytoma, are identiﬁed.
Brain Tumors by Richard Prayson MD, Bette K. Kleinschmidt-DeMasters MD, Mark Cohen MD, David E. Elder MB ChB