By Sergio Rosales-Mendoza
Genetically Engineered crops as a resource of Vaccines opposed to vast unfold ailments: An built-in View provides an built-in outlook of the disciplines interested by the advance of plant-based vaccines in addition to an up-to-date compilation of the profitable advancements within the box. the amount covers immunological points of mucosal vaccine layout, molecular techniques to realize excessive degrees of the recombinant antigens, the explanation of utilizing bioreactor to extend plant biomass, and pharmaceutical know-how methods which have been utilized to the advance of plant-based vaccine formulations. sensible figures and tables are offered to facilitate studying and id of key issues. views for this box also are discussed.
Written via specialists within the box, Genetically Engineered crops as a resource of Vaccines opposed to huge unfold ailments: An built-in View is a accomplished source for researchers and scholars drawn to plant genetics and breeding, immunology, and genetic engineering.
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Genetically Engineered crops as a resource of Vaccines opposed to huge unfold illnesses: An built-in View offers an built-in outlook of the disciplines curious about the improvement of plant-based vaccines in addition to an up-to-date compilation of the winning advancements within the box. the quantity covers immunological elements of mucosal vaccine layout, molecular methods to achieve excessive degrees of the recombinant antigens, the explanation of utilizing bioreactor to extend plant biomass, and pharmaceutical expertise ways which were utilized to the advance of plant-based vaccine formulations.
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Additional resources for Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View
J Am Chem Soc 134:13448–13457 Cheroutre H, Lambolez F, Mucida D (2011) The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol 11:445–456 40 A. L. García-Hernández et al. Coffman RL, Sher A, Seder RA (2010) Vaccine adjuvants: putting innate immunity to work. Immunity 33:492–503 Coombes JL, Powrie F (2008) Dendritic cells in intestinal immune regulation. Nat Rev Immunol 8:435–446 Daniell H, Singh ND, Mason H, Streatfield SJ (2009) Plant-made vaccine antigens and biopharmaceuticals.
Another method that has been employed to favor adhesion between epithelium and the vaccine delivery vehicle consists of using high-affinity targeting ligands against M cells, but only few M cell receptors had been identified. As M cells tend to exhibit unique glycosylation patterns, lectins such as Ulex europeus agglutinin 1 (UEA-1), which binds alpha-1-fucose, has been the most widely investigated M cell-targeting molecules in mice (Pavot et al. 2012). Accordingly, the effectiveness of live pathogens and effective oral vaccines such as the live poliovirus and live attenuated S.
Trends Immunol 30:23–32 Rescigno M (2011) The intestinal epithelial barrier in the control of homeostasis and immunity. Trends Immunol 32:256–264 Rojas-Hernández S, Rodríguez-Monroy MA, López-Revilla R, Reséndiz-Albor AA, MorenoFierros L (2004) Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis. Infect Immun 72:4368– 4375 Rosales-Mendoza S, Salazar-González JA (2014) Immunological aspects of using plant cells as delivery vehicles for oral vaccines.
Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View by Sergio Rosales-Mendoza